Enables actin binding activity; identical protein binding activity; and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Located in actin cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KLHL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KLHL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KLHL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:164,956,712–164,957,541 | 250.6 kb | Distal (>10kb) Multiome | 417 | |
| chr4:165,073,162–165,074,288 | 134.0 kb | Distal (>10kb) Multiome | 65 | |
| chr4:165,112,149–165,113,934 | 94.7 kb | Distal (>10kb) Multiome | 902 | |
| chr4:165,206,424–165,208,519 | 97 bp | At TSS Multiome | 645 | |
| chr4:165,212,564–165,213,138 | 5.0 kb | Proximal (<10kb) | 10 | |
| chr4:165,214,409–165,214,714 | 6.8 kb | Proximal (<10kb) | 10 | |
| chr4:165,326,454–165,328,403 | 120.0 kb | Distal (>10kb) Multiome HiCAR | 919 | |
| chr4:165,378,748–165,380,262 | 171.5 kb | Distal (>10kb) Multiome | 796 | |
| chr4:165,383,752–165,384,923 | 176.8 kb | Distal (>10kb) Multiome | 263 | |
| chr4:165,493,149–165,493,950 | 286.0 kb | Distal (>10kb) Multiome | 270 |
Genomic view of the KLHL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.