Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in positive regulation of mitotic cell cycle phase transition and protein ubiquitination. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KLHL18. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KLHL18 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KLHL18, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:46,987,364–46,988,143 | 295.3 kb | Distal (>10kb) Multiome | 452 | |
| chr3:46,998,405–46,998,990 | 284.2 kb | Distal (>10kb) Multiome | 400 | |
| chr3:47,008,983–47,010,119 | 273.4 kb | Distal (>10kb) Multiome | 328 | |
| chr3:47,024,824–47,025,334 | 257.8 kb | Distal (>10kb) Multiome HiCAR | 51 | |
| chr3:47,163,333–47,164,907 | 118.8 kb | Distal (>10kb) Multiome | 981 | |
| chr3:47,281,636–47,283,234 | 162 bp | At TSS Multiome | 941 | |
| chr3:47,380,120–47,381,966 | 98.0 kb | Distal (>10kb) Multiome | 1058 | |
| chr3:47,475,384–47,476,386 | 193.0 kb | Distal (>10kb) Multiome | 967 | |
| chr3:47,512,910–47,514,044 | 230.7 kb | Distal (>10kb) Multiome | 892 | |
| chr3:47,522,175–47,522,702 | 239.4 kb | Distal (>10kb) Multiome | 591 | |
| chr3:47,577,493–47,579,738 | 296.4 kb | Distal (>10kb) Multiome | 446 |
Genomic view of the KLHL18 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.