The protein encoded by this gene localizes to centrosomes, strengthening and stabilizing the pericentriolar region prior to spindle formation. The encoded protein usually remains with the mother centrosome after centrosomal duplication. Sevral transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Transcription factors with Perturb-seq knockdown data for KIZ. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIZ upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIZ, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:20,887,468–20,888,526 | 238.0 kb | Distal (>10kb) Multiome | 180 | |
| chr20:21,100,747–21,102,570 | 24.2 kb | Distal (>10kb) Multiome | 378 | |
| chr20:21,105,059–21,106,031 | 20.4 kb | Distal (>10kb) Multiome | 99 | |
| chr20:21,125,297–21,126,818 | 78 bp | At TSS Multiome | 907 | |
| chr20:21,189,624–21,190,699 | 64.2 kb | Distal (>10kb) Multiome | 265 | |
| chr20:21,302,879–21,304,081 | 177.4 kb | Distal (>10kb) Multiome | 1114 | |
| chr20:21,391,406–21,392,099 | 265.6 kb | Distal (>10kb) Multiome | 156 | |
| chr20:21,395,661–21,397,622 | 270.1 kb | Distal (>10kb) Multiome | 295 |
Genomic view of the KIZ locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.