The protein encoded by this gene is a kinesin heavy chain subunit involved in the transport of cargo within the central nervous system. The encoded protein, which acts as a tetramer by associating with another heavy chain and two light chains, interacts with protein kinase CK2. Mutations in this gene have been associated with complex cortical dysplasia with other brain malformations-2. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Jul 2015]
Transcription factors with Perturb-seq knockdown data for KIF5C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIF5C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIF5C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:148,577,566–148,579,047 | 296.9 kb | Distal (>10kb) Multiome | 183 | |
| chr2:148,643,868–148,646,256 | 229.9 kb | Distal (>10kb) Multiome | 1053 | |
| chr2:148,813,520–148,814,415 | 61.4 kb | Distal (>10kb) Multiome | 315 | |
| chr2:148,874,671–148,877,521 | 44 bp | At TSS Multiome | 652 | |
| chr2:148,998,911–149,000,002 | 124.2 kb | Distal (>10kb) Multiome | 79 | |
| chr2:149,037,769–149,039,431 | 163.5 kb | Distal (>10kb) Multiome | 414 | |
| chr2:149,124,742–149,125,882 | 250.1 kb | Distal (>10kb) Multiome | 256 |
Genomic view of the KIF5C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.