This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, Mar 2010]
Transcription factors with Perturb-seq knockdown data for KIF4A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIF4A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIF4A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:69,990,216–69,990,702 | 299.6 kb | Distal (>10kb) Multiome | 49 | |
| chrX:70,133,101–70,133,613 | 156.5 kb | Distal (>10kb) Multiome | 529 | |
| chrX:70,289,676–70,290,592 | 61 bp | At TSS Multiome | 481 | |
| chrX:70,433,669–70,435,047 | 144.4 kb | Distal (>10kb) Multiome | 638 | |
| chrX:70,452,116–70,452,807 | 162.3 kb | Distal (>10kb) Multiome | 254 | |
| chrX:70,454,439–70,455,911 | 164.8 kb | Distal (>10kb) Multiome | 546 | |
| chrX:70,508,261–70,509,156 | 218.5 kb | Distal (>10kb) Multiome | 203 |
Genomic view of the KIF4A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.