The protein encoded by this gene is an intracellular motor protein thought to transport organelles along microtubules. The encoded protein is required for kidney development. Elevated levels of this protein have been found in some breast and colorectal cancers. [provided by RefSeq, Mar 2017]
Transcription factors with Perturb-seq knockdown data for KIF26B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIF26B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIF26B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:244,862,633–244,865,438 | 290.3 kb | Distal (>10kb) Multiome | 1124 | |
| chr1:244,969,529–244,971,459 | 184.3 kb | Distal (>10kb) Multiome | 1136 | |
| chr1:245,051,083–245,052,207 | 103.3 kb | Distal (>10kb) Multiome | 353 | |
| chr1:245,093,040–245,095,301 | 60.7 kb | Distal (>10kb) Multiome | 322 | |
| chr1:245,153,093–245,157,406 | 1.7 kb | Proximal (<10kb) Multiome | 719 | |
| chr1:245,244,768–245,245,602 | 90.4 kb | Distal (>10kb) Multiome | 190 | |
| chr1:245,654,387–245,655,396 | 499.9 kb | Distal (>10kb) Multiome HiCAR | 149 | |
| chr1:245,813,164–245,813,824 | 658.5 kb | Distal (>10kb) Multiome HiCAR | 151 |
Genomic view of the KIF26B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.