This gene encodes a member of the kinesin superfamily. Kinesins are ATP-dependent microtubule-based motor proteins that are involved in the intracellular transport of membranous organelles. Single nucleotide polymorphisms in this gene are associated with inflammatory bowel disease and multiple sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Transcription factors with Perturb-seq knockdown data for KIF21B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIF21B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIF21B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:200,738,299–200,740,095 | 284.7 kb | Distal (>10kb) Multiome | 831 | |
| chr1:200,890,766–200,892,246 | 132.3 kb | Distal (>10kb) Multiome | 761 | |
| chr1:200,915,808–200,916,700 | 107.4 kb | Distal (>10kb) Multiome | 219 | |
| chr1:201,014,162–201,014,786 | 9.2 kb | Proximal (<10kb) Multiome | 160 | |
| chr1:201,015,562–201,016,315 | 7.1 kb | Proximal (<10kb) | 232 | |
| chr1:201,020,041–201,020,958 | 2.4 kb | Proximal (<10kb) | 289 | |
| chr1:201,021,071–201,021,621 | 2.4 kb | Proximal (<10kb) Multiome | 164 | |
| chr1:201,022,936–201,024,467 | 10 bp | At TSS Multiome | 436 | |
| chr1:201,113,946–201,115,250 | 90.6 kb | Distal (>10kb) Multiome HiCAR | 594 | |
| chr1:201,153,600–201,155,169 | 130.8 kb | Distal (>10kb) Multiome | 713 | |
| chr1:201,170,516–201,172,002 | 147.2 kb | Distal (>10kb) Multiome | 988 | |
| chr1:201,259,443–201,260,371 | 236.1 kb | Distal (>10kb) Multiome | 253 | |
| chr1:201,283,211–201,283,740 | 259.8 kb | Distal (>10kb) Multiome | 190 |
Genomic view of the KIF21B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.