Enables plus-end-directed microtubule motor activity. Involved in apoptotic process involved in development and mitochondrion transport along microtubule. Is active in mitochondrion. Implicated in Charcot-Marie-Tooth disease type 2A1; hepatocellular carcinoma; multiple sclerosis; neuroblastoma; and ovary epithelial cancer. Biomarker of hepatocellular carcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KIF1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIF1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIF1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:9,909,556–9,911,240 | 300.1 kb | Distal (>10kb) Multiome | 791 | |
| chr1:9,942,849–9,943,619 | 267.3 kb | Distal (>10kb) Multiome | 1015 | |
| chr1:10,032,377–10,033,814 | 177.7 kb | Distal (>10kb) Multiome | 891 | |
| chr1:10,209,800–10,211,585 | 154 bp | At TSS Multiome | 934 | |
| chr1:10,398,334–10,400,006 | 188.5 kb | Distal (>10kb) Multiome | 1064 | |
| chr1:10,430,062–10,431,244 | 220.0 kb | Distal (>10kb) Multiome | 1007 | |
| chr1:10,472,017–10,472,900 | 261.9 kb | Distal (>10kb) Multiome | 872 | |
| chr1:10,474,760–10,475,474 | 264.4 kb | Distal (>10kb) Multiome | 744 |
Genomic view of the KIF1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.