The protein encoded by this gene is a member of the kinesin family and functions as an anterograde motor protein that transports membranous organelles along axonal microtubules. Mutations at this locus have been associated with spastic paraplegia-30 and hereditary sensory neuropathy IIC. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]
Transcription factors with Perturb-seq knockdown data for KIF1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIF1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIF1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:240,557,164–240,558,401 | 262.2 kb | Distal (>10kb) Multiome | 226 | |
| chr2:240,560,183–240,561,566 | 259.9 kb | Distal (>10kb) Multiome | 1021 | |
| chr2:240,566,043–240,567,010 | 253.7 kb | Distal (>10kb) Multiome | 749 | |
| chr2:240,567,779–240,569,178 | 251.8 kb | Distal (>10kb) Multiome | 615 | |
| chr2:240,586,073–240,587,459 | 233.6 kb | Distal (>10kb) Multiome | 893 | |
| chr2:240,670,022–240,670,734 | 149.8 kb | Distal (>10kb) Multiome | 19 | |
| chr2:240,818,573–240,821,401 | 1.1 kb | Proximal (<10kb) Multiome | 419 | |
| chr2:240,832,084–240,832,795 | 12.2 kb | Distal (>10kb) Multiome | 307 | |
| chr2:240,902,359–240,903,515 | 82.7 kb | Distal (>10kb) Multiome | 217 | |
| chr2:240,997,873–240,999,416 | 178.3 kb | Distal (>10kb) Multiome | 439 | |
| chr2:241,009,658–241,010,603 | 189.8 kb | Distal (>10kb) Multiome | 314 | |
| chr2:241,102,057–241,102,727 | 282.2 kb | Distal (>10kb) Multiome | 1072 | |
| chr2:242,088,158–242,089,208 | 1268.5 kb | Distal (>10kb) Multiome HiCAR | 493 |
Genomic view of the KIF1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.