Located in cilium; intercellular bridge; and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KIAA1671. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIAA1671 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIAA1671, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:24,805,933–24,806,542 | 146.5 kb | Distal (>10kb) Multiome | 489 | |
| chr22:24,950,206–24,950,572 | 2.1 kb | Proximal (<10kb) | 133 | |
| chr22:24,951,976–24,953,813 | 158 bp | At TSS Multiome | 800 | |
| chr22:24,996,423–24,997,228 | 44.0 kb | Distal (>10kb) Multiome | 281 | |
| chr22:25,110,786–25,111,782 | 158.5 kb | Distal (>10kb) Multiome | 660 |
Genomic view of the KIAA1671 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.