Transcription factors with Perturb-seq knockdown data for KIAA0408. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIAA0408 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIAA0408, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:127,266,246–127,267,883 | 192.4 kb | Distal (>10kb) Multiome | 1001 | |
| chr6:127,297,458–127,298,045 | 161.7 kb | Distal (>10kb) Multiome | 248 | |
| chr6:127,342,123–127,344,593 | 116.0 kb | Distal (>10kb) Multiome | 975 | |
| chr6:127,449,486–127,450,099 | 9.3 kb | Proximal (<10kb) | 78 | |
| chr6:127,458,935–127,459,748 | at TSS | At TSS | 273 | |
| chr6:127,460,272–127,460,722 | 883 bp | At TSS | 37 | |
| chr6:127,464,966–127,465,556 | 5.6 kb | Proximal (<10kb) | 196 | |
| chr6:127,467,986–127,468,179 | 8.6 kb | Proximal (<10kb) | 4 | |
| chr6:127,483,397–127,484,154 | 24.2 kb | Distal (>10kb) Multiome | 288 | |
| chr6:127,514,397–127,517,019 | 57.2 kb | Distal (>10kb) Multiome | 855 | |
| chr6:127,518,139–127,519,697 | 59.7 kb | Distal (>10kb) Multiome | 431 |
Genomic view of the KIAA0408 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.