Enables RNA binding activity; identical protein binding activity; and protein domain specific binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome and spermatogenesis. Located in nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KHDRBS3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KHDRBS3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KHDRBS3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:135,395,933–135,397,727 | 61.0 kb | Distal (>10kb) Multiome | 270 | |
| chr8:135,398,287–135,399,092 | 58.8 kb | Distal (>10kb) Multiome | 113 | |
| chr8:135,452,439–135,452,616 | 4.8 kb | Proximal (<10kb) | 145 | |
| chr8:135,456,036–135,459,111 | 52 bp | At TSS Multiome | 758 | |
| chr8:135,463,097–135,463,253 | 5.6 kb | Proximal (<10kb) | 4 | |
| chr8:135,463,357–135,463,562 | 5.9 kb | Proximal (<10kb) | 16 | |
| chr8:135,463,675–135,463,921 | 6.2 kb | Proximal (<10kb) | 32 | |
| chr8:135,465,958–135,466,326 | 8.5 kb | Proximal (<10kb) | 103 | |
| chr8:135,494,479–135,495,434 | 37.4 kb | Distal (>10kb) Multiome | 106 | |
| chr8:135,731,713–135,732,833 | 274.9 kb | Distal (>10kb) Multiome | 95 | |
| chr8:135,790,206–135,791,240 | 333.3 kb | Distal (>10kb) Multiome HiCAR | 110 |
Genomic view of the KHDRBS3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.