This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The encoded protein appears to have many functions and may be involved in a variety of cellular processes, including alternative splicing, cell cycle regulation, RNA 3'-end formation, tumorigenesis, and regulation of human immunodeficiency virus gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Transcription factors with Perturb-seq knockdown data for KHDRBS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KHDRBS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KHDRBS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:31,714,302–31,716,109 | 298.6 kb | Distal (>10kb) Multiome | 759 | |
| chr1:31,760,521–31,761,442 | 253.0 kb | Distal (>10kb) Multiome | 317 | |
| chr1:31,762,648–31,763,343 | 251.1 kb | Distal (>10kb) Multiome | 402 | |
| chr1:31,764,083–31,764,672 | 249.5 kb | Distal (>10kb) Multiome | 263 | |
| chr1:31,769,677–31,770,397 | 243.7 kb | Distal (>10kb) Multiome | 185 | |
| chr1:31,776,109–31,776,832 | 237.3 kb | Distal (>10kb) Multiome | 86 | |
| chr1:31,788,126–31,789,694 | 225.2 kb | Distal (>10kb) Multiome | 713 | |
| chr1:31,815,736–31,816,251 | 197.8 kb | Distal (>10kb) Multiome | 666 | |
| chr1:31,937,587–31,938,944 | 75.4 kb | Distal (>10kb) Multiome | 1111 | |
| chr1:31,943,994–31,945,090 | 69.3 kb | Distal (>10kb) Multiome | 826 | |
| chr1:31,954,721–31,955,545 | 58.7 kb | Distal (>10kb) Multiome | 628 | |
| chr1:31,964,141–31,964,595 | 49.6 kb | Distal (>10kb) Multiome | 529 | |
| chr1:32,013,168–32,015,085 | 185 bp | At TSS Multiome | 988 | |
| chr1:32,072,319–32,073,738 | 59.3 kb | Distal (>10kb) Multiome | 909 | |
| chr1:32,107,881–32,108,706 | 94.2 kb | Distal (>10kb) Multiome | 779 | |
| chr1:32,179,263–32,180,190 | 165.9 kb | Distal (>10kb) Multiome | 1019 | |
| chr1:32,200,233–32,201,756 | 186.8 kb | Distal (>10kb) Multiome | 573 | |
| chr1:32,204,985–32,206,258 | 191.7 kb | Distal (>10kb) Multiome | 679 | |
| chr1:32,221,877–32,222,889 | 208.5 kb | Distal (>10kb) Multiome | 755 | |
| chr1:32,239,728–32,240,979 | 226.5 kb | Distal (>10kb) Multiome | 456 | |
| chr1:32,248,081–32,248,895 | 234.6 kb | Distal (>10kb) Multiome | 622 | |
| chr1:32,291,710–32,292,726 | 278.2 kb | Distal (>10kb) Multiome | 900 |
Genomic view of the KHDRBS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.