This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for KEL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KEL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KEL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:142,748,805–142,749,672 | 213.1 kb | Distal (>10kb) Multiome | 74 | |
| chr7:142,770,332–142,771,391 | 191.5 kb | Distal (>10kb) Multiome | 150 | |
| chr7:142,782,876–142,783,641 | 179.1 kb | Distal (>10kb) Multiome | 448 | |
| chr7:142,853,711–142,856,176 | 107.4 kb | Distal (>10kb) Multiome | 583 | |
| chr7:142,885,313–142,886,162 | 76.6 kb | Distal (>10kb) Multiome HiCAR | 160 | |
| chr7:142,956,998–142,957,676 | 4.7 kb | Proximal (<10kb) | 202 | |
| chr7:142,958,755–142,958,929 | 3.4 kb | Proximal (<10kb) | 6 | |
| chr7:142,962,138–142,962,531 | at TSS | At TSS | 232 | |
| chr7:142,962,959–142,963,343 | 596 bp | At TSS | 15 | |
| chr7:143,041,996–143,043,331 | 80.5 kb | Distal (>10kb) Multiome | 258 |
Genomic view of the KEL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.