Transcription factors with Perturb-seq knockdown data for KDM2B-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KDM2B-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KDM2B-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:121,280,329–121,281,482 | 299.9 kb | Distal (>10kb) Multiome | 112 | |
| chr12:121,295,441–121,297,879 | 283.9 kb | Distal (>10kb) Multiome | 801 | |
| chr12:121,351,979–121,352,906 | 228.3 kb | Distal (>10kb) Multiome | 928 | |
| chr12:121,399,561–121,400,983 | 180.8 kb | Distal (>10kb) Multiome | 923 | |
| chr12:121,443,293–121,443,776 | 137.3 kb | Distal (>10kb) Multiome | 302 | |
| chr12:121,466,702–121,468,225 | 113.3 kb | Distal (>10kb) Multiome | 643 | |
| chr12:121,536,039–121,536,480 | 44.4 kb | Distal (>10kb) Multiome | 262 | |
| chr12:121,576,794–121,577,632 | 3.7 kb | Proximal (<10kb) Multiome | 171 | |
| chr12:121,578,232–121,579,405 | 1.4 kb | Proximal (<10kb) | 272 | |
| chr12:121,580,160–121,581,909 | 336 bp | At TSS Multiome | 629 | |
| chr12:121,582,525–121,583,038 | 2.1 kb | Proximal (<10kb) Multiome | 309 | |
| chr12:121,590,245–121,590,431 | 9.5 kb | Proximal (<10kb) | 323 | |
| chr12:121,625,878–121,627,559 | 45.7 kb | Distal (>10kb) Multiome HiCAR | 904 | |
| chr12:121,671,731–121,673,334 | 91.8 kb | Distal (>10kb) Multiome HiCAR | 548 | |
| chr12:121,686,676–121,687,782 | 106.3 kb | Distal (>10kb) Multiome | 907 | |
| chr12:121,712,130–121,713,412 | 132.0 kb | Distal (>10kb) Multiome | 731 | |
| chr12:121,792,642–121,795,650 | 213.3 kb | Distal (>10kb) Multiome | 1009 | |
| chr12:121,797,071–121,801,369 | 217.8 kb | Distal (>10kb) Multiome | 1126 | |
| chr12:121,802,658–121,804,393 | 222.3 kb | Distal (>10kb) Multiome | 825 | |
| chr12:121,812,380–121,813,114 | 231.6 kb | Distal (>10kb) Multiome | 458 | |
| chr12:121,839,137–121,840,260 | 258.8 kb | Distal (>10kb) Multiome | 564 |
Genomic view of the KDM2B-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.