The protein encoded by this gene binds proliferating cell nuclear antigen (PCNA) and may be involved in DNA synthesis and cell proliferation. In addition, the encoded protein may be a tumor suppressor. Several protein-coding and non-protein coding transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for KCTD10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KCTD10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KCTD10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:109,308,986–109,310,221 | 168.0 kb | Distal (>10kb) Multiome | 331 | |
| chr12:109,476,943–109,477,929 | 94 bp | At TSS Multiome | 911 | |
| chr12:109,573,025–109,574,078 | 96.3 kb | Distal (>10kb) Multiome | 1005 | |
| chr12:109,597,611–109,598,240 | 120.6 kb | Distal (>10kb) Multiome | 536 | |
| chr12:109,679,688–109,680,306 | 202.8 kb | Distal (>10kb) Multiome | 69 | |
| chr12:109,697,996–109,698,635 | 221.0 kb | Distal (>10kb) Multiome | 115 | |
| chr12:109,713,288–109,715,156 | 236.4 kb | Distal (>10kb) Multiome | 793 | |
| chr12:109,717,933–109,718,896 | 241.2 kb | Distal (>10kb) Multiome | 199 | |
| chr12:109,737,442–109,738,212 | 260.6 kb | Distal (>10kb) Multiome | 231 | |
| chr12:109,739,699–109,741,057 | 262.9 kb | Distal (>10kb) Multiome | 245 |
Genomic view of the KCTD10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.