KCTD1

potassium channel tetramerization domain containing 1 | C18orf5

This gene encodes a protein containing a BTB (Broad-complex, tramtrack and bric a brac), also known as a POZ (POxvirus and zinc finger) protein-protein interaction domain. The encoded protein negatively regulates the AP-2 family of transcription factors and the Wnt signaling pathway. A mechanism for the modulation of Wnt signaling has been proposed in which the encoded protein enhances ubiquitination and degradation of the beta-catenin protein. Mutations in this gene have been identified in Scalp-ear-nipple (SEN) syndrome. [provided by RefSeq, May 2017]

Member of: DE-4

Biological processes 16 terms

identical protein binding (GO:0042802)identical protein binding (GO:0042802)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of Notch signaling pathway (GO:0045746)negative regulation of canonical Wnt signaling pathway (GO:0090090)negative regulation of smoothened signaling pathway (GO:0045879)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)protein homooligomerization (GO:0051260)transcription corepressor activity (GO:0003714)transcription corepressor activity (GO:0003714)transcription factor binding (GO:0008134)

Expression (TPM)

TFs regulating KCTD1 0 TFs

Transcription factors with Perturb-seq knockdown data for KCTD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KCTD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to KCTD1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KCTD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr18:26,457,727–26,458,252	199.3 kb	Distal (>10kb) Multiome	110
chr18:26,546,875–26,550,290	108.8 kb	Distal (>10kb) Multiome	641
chr18:26,550,411–26,551,223	106.4 kb	Distal (>10kb) Multiome	242
chr18:26,648,070–26,650,001	8.2 kb	Proximal (<10kb) Multiome	408
chr18:26,650,889–26,651,492	6.3 kb	Proximal (<10kb) Multiome	74
chr18:26,655,726–26,657,561	202 bp	At TSS Multiome	533
chr18:26,664,459–26,664,656	7.1 kb	Proximal (<10kb)	8
chr18:26,709,971–26,711,052	53.1 kb	Distal (>10kb) Multiome	287
chr18:26,863,119–26,863,780	206.0 kb	Distal (>10kb) Multiome	279
chr18:26,956,953–26,957,443	299.7 kb	Distal (>10kb) Multiome	152

Genome Browser

Genomic view of the KCTD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.