Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for KCNN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KCNN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KCNN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:17,686,280–17,688,656 | 264.5 kb | Distal (>10kb) Multiome | 586 | |
| chr19:17,719,144–17,719,957 | 231.8 kb | Distal (>10kb) Multiome | 585 | |
| chr19:17,747,227–17,748,170 | 203.6 kb | Distal (>10kb) Multiome | 503 | |
| chr19:17,762,487–17,762,985 | 188.6 kb | Distal (>10kb) Multiome | 199 | |
| chr19:17,778,112–17,778,869 | 172.9 kb | Distal (>10kb) Multiome | 311 | |
| chr19:17,794,880–17,795,385 | 156.2 kb | Distal (>10kb) Multiome | 465 | |
| chr19:17,829,926–17,831,824 | 120.3 kb | Distal (>10kb) Multiome | 466 | |
| chr19:17,841,205–17,843,221 | 109.2 kb | Distal (>10kb) Multiome | 545 | |
| chr19:17,847,546–17,848,187 | 103.6 kb | Distal (>10kb) Multiome | 437 | |
| chr19:17,859,472–17,860,202 | 91.5 kb | Distal (>10kb) Multiome | 822 | |
| chr19:17,873,769–17,874,763 | 77.0 kb | Distal (>10kb) Multiome | 303 | |
| chr19:17,931,700–17,932,248 | 19.4 kb | Distal (>10kb) Multiome | 136 | |
| chr19:17,932,373–17,933,607 | 18.5 kb | Distal (>10kb) Multiome | 924 | |
| chr19:17,942,639–17,943,673 | 8.0 kb | Proximal (<10kb) Multiome | 302 | |
| chr19:17,946,208–17,946,748 | 4.5 kb | Proximal (<10kb) | 276 | |
| chr19:17,947,203–17,950,613 | 3.2 kb | Proximal (<10kb) Multiome | 639 | |
| chr19:17,950,724–17,951,089 | 202 bp | At TSS | 196 | |
| chr19:17,951,201–17,952,652 | 962 bp | At TSS Multiome | 237 | |
| chr19:17,966,756–17,967,353 | 15.8 kb | Distal (>10kb) Multiome | 127 | |
| chr19:18,000,754–18,001,614 | 49.9 kb | Distal (>10kb) Multiome | 788 | |
| chr19:18,007,024–18,008,451 | 56.8 kb | Distal (>10kb) Multiome | 681 | |
| chr19:18,058,070–18,058,878 | 107.2 kb | Distal (>10kb) Multiome | 542 | |
| chr19:18,104,219–18,104,847 | 153.2 kb | Distal (>10kb) Multiome | 466 | |
| chr19:18,109,636–18,110,594 | 158.8 kb | Distal (>10kb) Multiome | 601 | |
| chr19:18,117,556–18,118,528 | 166.7 kb | Distal (>10kb) Multiome | 550 | |
| chr19:18,152,230–18,153,823 | 201.6 kb | Distal (>10kb) Multiome | 809 | |
| chr19:18,160,950–18,161,791 | 210.1 kb | Distal (>10kb) Multiome | 494 | |
| chr19:18,173,513–18,174,441 | 222.5 kb | Distal (>10kb) Multiome | 667 | |
| chr19:18,192,530–18,193,908 | 241.7 kb | Distal (>10kb) Multiome | 758 | |
| chr19:18,202,796–18,205,452 | 253.0 kb | Distal (>10kb) Multiome | 823 | |
| chr19:18,220,660–18,221,487 | 269.7 kb | Distal (>10kb) Multiome | 134 | |
| chr19:18,223,665–18,226,306 | 272.7 kb | Distal (>10kb) Multiome | 790 | |
| chr19:18,232,737–18,233,413 | 281.9 kb | Distal (>10kb) Multiome | 789 |
Genomic view of the KCNN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.