MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for KCNMB4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KCNMB4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KCNMB4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:70,073,753–70,075,125 | 291.8 kb | Distal (>10kb) Multiome | 194 | |
| chr12:70,242,658–70,244,375 | 123.0 kb | Distal (>10kb) Multiome | 1001 | |
| chr12:70,360,732–70,361,009 | 5.3 kb | Proximal (<10kb) | 70 | |
| chr12:70,365,146–70,367,979 | 9 bp | At TSS Multiome | 710 | |
| chr12:70,554,707–70,555,639 | 189.0 kb | Distal (>10kb) Multiome | 174 |
Genomic view of the KCNMB4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.