Transcription factors with Perturb-seq knockdown data for KBTBD11-OT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KBTBD11-OT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KBTBD11-OT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:1,755,576–1,755,881 | 8.0 kb | Proximal (<10kb) | 390 | |
| chr8:1,758,564–1,759,241 | 4.6 kb | Proximal (<10kb) | 124 | |
| chr8:1,759,396–1,759,708 | 4.2 kb | Proximal (<10kb) | 41 | |
| chr8:1,762,735–1,763,431 | 455 bp | At TSS | 366 | |
| chr8:1,763,611–1,765,449 | at TSS | At TSS | 769 | |
| chr8:1,765,557–1,766,098 | 1.7 kb | Proximal (<10kb) | 71 |
Genomic view of the KBTBD11-OT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.