Transcription factors with Perturb-seq knockdown data for KBTBD11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KBTBD11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KBTBD11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:1,700,997–1,701,729 | 272.3 kb | Distal (>10kb) Multiome | 300 | |
| chr8:1,763,611–1,765,449 | 210.0 kb | Distal (>10kb) Multiome | 769 | |
| chr8:1,801,852–1,803,309 | 170.9 kb | Distal (>10kb) Multiome | 182 | |
| chr8:1,816,753–1,817,762 | 156.5 kb | Distal (>10kb) Multiome | 113 | |
| chr8:1,823,171–1,824,563 | 149.9 kb | Distal (>10kb) Multiome | 514 | |
| chr8:1,973,169–1,973,288 | 387 bp | At TSS | 132 | |
| chr8:1,973,408–1,974,934 | 212 bp | At TSS Multiome | 298 | |
| chr8:1,978,059–1,978,244 | 4.4 kb | Proximal (<10kb) | 9 | |
| chr8:2,000,722–2,003,182 | 28.1 kb | Distal (>10kb) Multiome | 414 | |
| chr8:2,063,936–2,064,980 | 91.0 kb | Distal (>10kb) Multiome | 138 | |
| chr8:2,156,048–2,156,762 | 182.8 kb | Distal (>10kb) Multiome | 150 | |
| chr8:2,196,983–2,198,202 | 224.0 kb | Distal (>10kb) Multiome | 93 |
Genomic view of the KBTBD11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.