Enables identical protein binding activity and microtubule severing ATPase activity. Involved in microtubule severing. Located in cytosol; microtubule cytoskeleton; and mitochondrion. Part of katanin complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KATNAL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KATNAL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KATNAL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:30,031,400–30,031,991 | 275.2 kb | Distal (>10kb) Multiome | 77 | |
| chr13:30,042,195–30,043,012 | 264.4 kb | Distal (>10kb) Multiome | 60 | |
| chr13:30,051,597–30,052,771 | 254.6 kb | Distal (>10kb) Multiome | 229 | |
| chr13:30,076,912–30,078,136 | 229.3 kb | Distal (>10kb) Multiome | 193 | |
| chr13:30,112,660–30,113,240 | 193.9 kb | Distal (>10kb) Multiome | 269 | |
| chr13:30,114,642–30,115,460 | 191.8 kb | Distal (>10kb) Multiome | 617 | |
| chr13:30,132,589–30,133,092 | 174.1 kb | Distal (>10kb) Multiome HiCAR | 342 | |
| chr13:30,182,219–30,182,971 | 124.4 kb | Distal (>10kb) Multiome | 134 | |
| chr13:30,306,729–30,307,939 | 280 bp | At TSS Multiome | 756 | |
| chr13:30,408,104–30,408,932 | 101.7 kb | Distal (>10kb) Multiome | 692 | |
| chr13:30,421,116–30,422,727 | 115.3 kb | Distal (>10kb) Multiome | 513 | |
| chr13:30,445,442–30,446,304 | 139.0 kb | Distal (>10kb) Multiome | 484 | |
| chr13:30,464,236–30,465,228 | 157.9 kb | Distal (>10kb) Multiome | 645 | |
| chr13:30,465,545–30,466,629 | 159.2 kb | Distal (>10kb) Multiome | 658 |
Genomic view of the KATNAL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.