This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with an autosomal dominant form of cognitive disability. Chromosomal translocations of this gene are associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
Transcription factors with Perturb-seq knockdown data for KAT6A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KAT6A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KAT6A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:41,701,707–41,702,358 | 350.1 kb | Distal (>10kb) Multiome | 481 | |
| chr8:41,766,804–41,768,073 | 284.6 kb | Distal (>10kb) Multiome | 304 | |
| chr8:41,791,812–41,792,404 | 259.8 kb | Distal (>10kb) Multiome | 574 | |
| chr8:41,818,697–41,819,374 | 233.0 kb | Distal (>10kb) Multiome | 577 | |
| chr8:41,828,115–41,829,096 | 223.5 kb | Distal (>10kb) Multiome | 805 | |
| chr8:41,895,762–41,897,697 | 155.9 kb | Distal (>10kb) Multiome | 781 | |
| chr8:42,010,489–42,011,119 | 41.2 kb | Distal (>10kb) Multiome | 127 | |
| chr8:42,050,725–42,052,921 | 223 bp | At TSS Multiome | 1042 | |
| chr8:42,139,747–42,140,990 | 88.7 kb | Distal (>10kb) Multiome HiCAR | 779 | |
| chr8:42,151,983–42,153,808 | 100.9 kb | Distal (>10kb) Multiome | 975 | |
| chr8:42,270,718–42,271,870 | 219.3 kb | Distal (>10kb) Multiome | 668 | |
| chr8:42,337,948–42,339,165 | 286.5 kb | Distal (>10kb) Multiome | 710 |
Genomic view of the KAT6A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.