Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within several processes, including endocytosis; membrane biogenesis; and protein deubiquitination. Located in membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for JOSD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = JOSD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of JOSD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:38,455,555–38,456,345 | 245.0 kb | Distal (>10kb) Multiome | 403 | |
| chr22:38,461,291–38,461,848 | 239.4 kb | Distal (>10kb) Multiome | 595 | |
| chr22:38,505,466–38,506,961 | 194.5 kb | Distal (>10kb) Multiome | 889 | |
| chr22:38,569,664–38,571,256 | 130.7 kb | Distal (>10kb) Multiome | 559 | |
| chr22:38,655,982–38,657,104 | 44.6 kb | Distal (>10kb) Multiome | 698 | |
| chr22:38,681,730–38,682,262 | 19.1 kb | Distal (>10kb) Multiome | 947 | |
| chr22:38,700,377–38,701,744 | 52 bp | At TSS Multiome | 916 | |
| chr22:38,705,151–38,706,595 | 4.7 kb | Proximal (<10kb) Multiome | 821 | |
| chr22:38,755,428–38,756,383 | 55.0 kb | Distal (>10kb) Multiome | 770 | |
| chr22:38,793,674–38,794,378 | 93.1 kb | Distal (>10kb) Multiome | 484 | |
| chr22:38,843,207–38,844,443 | 142.8 kb | Distal (>10kb) Multiome | 585 | |
| chr22:38,866,394–38,866,832 | 165.5 kb | Distal (>10kb) Multiome | 76 | |
| chr22:38,871,208–38,873,237 | 171.3 kb | Distal (>10kb) Multiome | 758 |
Genomic view of the JOSD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.