Transcription factors with Perturb-seq knockdown data for JAKMIP2-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = JAKMIP2-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of JAKMIP2-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:147,452,160–147,452,760 | 107.7 kb | Distal (>10kb) Multiome HiCAR | 144 | |
| chr5:147,453,007–147,454,909 | 105.9 kb | Distal (>10kb) Multiome HiCAR | 558 | |
| chr5:147,508,911–147,510,481 | 50.0 kb | Distal (>10kb) Multiome HiCAR | 440 | |
| chr5:147,558,945–147,559,166 | 826 bp | At TSS | 91 | |
| chr5:147,560,965–147,561,370 | 972 bp | At TSS | 85 | |
| chr5:147,567,516–147,569,131 | 8.1 kb | Proximal (<10kb) Multiome | 324 | |
| chr5:147,782,086–147,783,019 | 222.8 kb | Distal (>10kb) Multiome | 348 |
Genomic view of the JAKMIP2-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.