Involved in regulation of mRNA export from nucleus; regulation of mRNA processing; and transcription elongation-coupled chromatin remodeling. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for IWS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IWS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IWS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:127,293,716–127,294,914 | 232.3 kb | Distal (>10kb) Multiome | 876 | |
| chr2:127,386,971–127,388,844 | 139.1 kb | Distal (>10kb) Multiome | 986 | |
| chr2:127,407,631–127,408,983 | 118.3 kb | Distal (>10kb) Multiome | 878 | |
| chr2:127,415,703–127,416,595 | 110.4 kb | Distal (>10kb) Multiome | 501 | |
| chr2:127,422,503–127,423,812 | 103.2 kb | Distal (>10kb) Multiome | 321 | |
| chr2:127,463,310–127,464,007 | 62.8 kb | Distal (>10kb) Multiome | 176 | |
| chr2:127,522,136–127,522,565 | 3.9 kb | Proximal (<10kb) | 11 | |
| chr2:127,525,984–127,528,084 | 115 bp | At TSS Multiome | 1026 | |
| chr2:127,528,295–127,528,988 | 1.8 kb | Proximal (<10kb) | 58 | |
| chr2:127,542,311–127,543,476 | 16.7 kb | Distal (>10kb) Multiome | 233 | |
| chr2:127,591,279–127,591,967 | 65.1 kb | Distal (>10kb) Multiome | 431 | |
| chr2:127,674,653–127,675,849 | 148.8 kb | Distal (>10kb) Multiome | 324 | |
| chr2:127,700,417–127,702,395 | 175.1 kb | Distal (>10kb) Multiome | 1115 | |
| chr2:127,810,532–127,811,650 | 284.7 kb | Distal (>10kb) Multiome | 948 |
Genomic view of the IWS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.