This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ITGB8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ITGB8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ITGB8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:20,053,213–20,053,692 | 277.1 kb | Distal (>10kb) Multiome | 21 | |
| chr7:20,086,466–20,087,310 | 243.8 kb | Distal (>10kb) Multiome | 54 | |
| chr7:20,120,210–20,122,603 | 209.8 kb | Distal (>10kb) Multiome | 276 | |
| chr7:20,125,703–20,126,837 | 204.4 kb | Distal (>10kb) Multiome | 167 | |
| chr7:20,217,098–20,217,914 | 113.2 kb | Distal (>10kb) Multiome | 460 | |
| chr7:20,219,096–20,220,603 | 110.7 kb | Distal (>10kb) Multiome | 899 | |
| chr7:20,329,378–20,332,363 | 891 bp | At TSS Multiome | 815 | |
| chr7:20,439,475–20,441,186 | 110.0 kb | Distal (>10kb) Multiome | 130 |
Genomic view of the ITGB8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.