This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for VCAM1, cytotactin and osteopontin. Expression of this gene has been found to be upregulated in small cell lung cancers. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ITGA9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ITGA9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ITGA9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:37,175,555–37,176,875 | 275.8 kb | Distal (>10kb) Multiome | 907 | |
| chr3:37,242,726–37,244,363 | 208.8 kb | Distal (>10kb) Multiome | 969 | |
| chr3:37,451,532–37,454,321 | 22 bp | At TSS Multiome | 422 | |
| chr3:37,457,727–37,457,980 | 5.6 kb | Proximal (<10kb) | 36 | |
| chr3:37,458,272–37,458,730 | 6.2 kb | Proximal (<10kb) | 104 | |
| chr3:37,504,384–37,505,247 | 52.7 kb | Distal (>10kb) Multiome HiCAR | 181 | |
| chr3:37,531,867–37,532,817 | 80.3 kb | Distal (>10kb) Multiome HiCAR | 142 | |
| chr3:37,693,741–37,694,487 | 242.0 kb | Distal (>10kb) Multiome | 152 | |
| chr3:37,993,686–37,994,594 | 542.2 kb | Distal (>10kb) Multiome HiCAR | 519 | |
| chr3:37,998,336–37,999,630 | 547.0 kb | Distal (>10kb) Multiome HiCAR | 510 |
Genomic view of the ITGA9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.