ISOC2

isochorismatase domain containing 2 | FLJ23469

Involved in protein destabilization. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-1

Biological processes 9 terms

cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)mitochondrion (GO:0005739)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)protein destabilization (GO:0031648)

Expression (TPM)

TFs regulating ISOC2 0 TFs

Transcription factors with Perturb-seq knockdown data for ISOC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ISOC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ISOC2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ISOC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:55,091,780–55,093,292	369.3 kb	Distal (>10kb) Multiome HiCAR	208
chr19:55,095,398–55,095,977	365.8 kb	Distal (>10kb) Multiome HiCAR	90
chr19:55,117,134–55,119,109	343.9 kb	Distal (>10kb) Multiome HiCAR	881
chr19:55,165,952–55,167,256	294.9 kb	Distal (>10kb) Multiome	719
chr19:55,173,717–55,174,287	287.6 kb	Distal (>10kb) Multiome	330
chr19:55,178,876–55,179,477	282.5 kb	Distal (>10kb) Multiome	479
chr19:55,216,490–55,217,227	244.8 kb	Distal (>10kb) Multiome	1077
chr19:55,257,751–55,259,635	202.4 kb	Distal (>10kb) Multiome	1054
chr19:55,279,599–55,280,933	181.4 kb	Distal (>10kb) Multiome	805
chr19:55,283,835–55,284,716	177.6 kb	Distal (>10kb) Multiome	242
chr19:55,301,640–55,302,240	159.7 kb	Distal (>10kb) Multiome	448
chr19:55,338,676–55,340,358	122.1 kb	Distal (>10kb) Multiome	882
chr19:55,340,675–55,341,535	120.3 kb	Distal (>10kb) Multiome	368
chr19:55,353,720–55,354,487	107.5 kb	Distal (>10kb) Multiome	297
chr19:55,369,099–55,370,447	91.6 kb	Distal (>10kb) Multiome	383
chr19:55,383,539–55,384,553	77.7 kb	Distal (>10kb) Multiome	374
chr19:55,384,697–55,386,560	75.9 kb	Distal (>10kb) Multiome	903
chr19:55,406,950–55,408,675	53.6 kb	Distal (>10kb) Multiome	965
chr19:55,452,738–55,453,308	8.6 kb	Proximal (<10kb) Multiome	339
chr19:55,460,784–55,462,230	166 bp	At TSS Multiome	947
chr19:55,467,690–55,468,054	6.0 kb	Proximal (<10kb)	491
chr19:55,476,048–55,477,307	15.0 kb	Distal (>10kb) Multiome	1007
chr19:55,484,846–55,485,682	23.5 kb	Distal (>10kb) Multiome	594
chr19:55,503,638–55,504,310	42.4 kb	Distal (>10kb) Multiome	710
chr19:55,516,768–55,517,459	55.5 kb	Distal (>10kb) Multiome	583
chr19:55,536,923–55,537,366	75.5 kb	Distal (>10kb) Multiome	180
chr19:55,549,822–55,550,343	88.4 kb	Distal (>10kb) Multiome	396
chr19:55,580,080–55,581,090	119.2 kb	Distal (>10kb) Multiome	718
chr19:55,585,644–55,586,314	124.2 kb	Distal (>10kb) Multiome	370
chr19:55,586,698–55,587,594	125.7 kb	Distal (>10kb) Multiome	463
chr19:55,598,551–55,600,991	138.8 kb	Distal (>10kb) Multiome	1018
chr19:55,604,520–55,606,690	143.7 kb	Distal (>10kb) Multiome	820
chr19:55,623,637–55,625,055	162.9 kb	Distal (>10kb) Multiome	650
chr19:55,640,091–55,641,769	179.4 kb	Distal (>10kb) Multiome	821
chr19:55,642,197–55,644,356	181.9 kb	Distal (>10kb) Multiome	884
chr19:55,647,711–55,648,342	186.4 kb	Distal (>10kb) Multiome	671
chr19:55,652,138–55,653,078	190.8 kb	Distal (>10kb) Multiome	105
chr19:55,653,199–55,656,056	193.0 kb	Distal (>10kb) Multiome	1123
chr19:55,674,767–55,675,613	213.5 kb	Distal (>10kb) Multiome	765

Genome Browser

Genomic view of the ISOC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.