This gene encodes a member of the IQGAP family. The encoded protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. This protein interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. It also acts as a tumor suppressor and has been found to play a role in regulating innate antiviral responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
Transcription factors with Perturb-seq knockdown data for IQGAP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IQGAP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IQGAP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:76,303,845–76,304,490 | 99.2 kb | Distal (>10kb) Multiome | 222 | |
| chr5:76,337,873–76,338,418 | 65.2 kb | Distal (>10kb) Multiome | 277 | |
| chr5:76,367,794–76,368,362 | 35.1 kb | Distal (>10kb) Multiome | 107 | |
| chr5:76,402,279–76,404,361 | 808 bp | At TSS Multiome | 1013 | |
| chr5:76,407,160–76,407,352 | 3.9 kb | Proximal (<10kb) | 12 | |
| chr5:76,504,460–76,505,155 | 101.5 kb | Distal (>10kb) Multiome | 40 | |
| chr5:76,548,249–76,549,423 | 145.4 kb | Distal (>10kb) Multiome HiCAR | 149 |
Genomic view of the IQGAP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.