Transcription factors with Perturb-seq knockdown data for IQCH-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IQCH-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IQCH-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:67,254,178–67,255,165 | 266.8 kb | Distal (>10kb) Multiome | 964 | |
| chr15:67,267,516–67,268,376 | 253.6 kb | Distal (>10kb) Multiome | 61 | |
| chr15:67,474,546–67,475,121 | 46.8 kb | Distal (>10kb) Multiome | 32 | |
| chr15:67,520,813–67,522,002 | 198 bp | At TSS Multiome | 1071 | |
| chr15:67,542,323–67,543,328 | 21.2 kb | Distal (>10kb) Multiome | 734 | |
| chr15:67,782,016–67,782,994 | 260.7 kb | Distal (>10kb) Multiome HiCAR | 131 |
Genomic view of the IQCH-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.