Involved in limb morphogenesis. Predicted to be located in cytoplasmic side of plasma membrane. Predicted to be part of plasma membrane protein complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for IQCE. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IQCE upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IQCE, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:2,313,875–2,314,819 | 244.6 kb | Distal (>10kb) Multiome | 684 | |
| chr7:2,353,760–2,355,437 | 204.4 kb | Distal (>10kb) Multiome | 1060 | |
| chr7:2,403,048–2,404,583 | 155.6 kb | Distal (>10kb) Multiome | 775 | |
| chr7:2,451,319–2,452,043 | 107.5 kb | Distal (>10kb) Multiome | 660 | |
| chr7:2,518,679–2,520,557 | 39.4 kb | Distal (>10kb) Multiome HiCAR | 567 | |
| chr7:2,555,131–2,556,097 | 3.3 kb | Proximal (<10kb) Multiome | 772 | |
| chr7:2,558,641–2,559,572 | 61 bp | At TSS Multiome | 669 | |
| chr7:2,631,170–2,632,859 | 72.7 kb | Distal (>10kb) Multiome | 658 | |
| chr7:2,646,545–2,647,390 | 88.0 kb | Distal (>10kb) Multiome HiCAR | 245 | |
| chr7:2,688,023–2,688,723 | 129.2 kb | Distal (>10kb) Multiome | 176 | |
| chr7:2,706,487–2,707,069 | 147.8 kb | Distal (>10kb) Multiome | 81 | |
| chr7:2,709,414–2,710,178 | 150.8 kb | Distal (>10kb) Multiome | 481 | |
| chr7:2,821,232–2,821,746 | 262.5 kb | Distal (>10kb) Multiome | 210 | |
| chr7:2,843,825–2,845,052 | 285.4 kb | Distal (>10kb) Multiome | 635 |
Genomic view of the IQCE locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.