This gene encodes a subunit of the integrator complex. The integrator complex associates with the C-terminal domain of RNA polymerase II and mediates 3'-end processing of the small nuclear RNAs U1 and U2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for INTS7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = INTS7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of INTS7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:211,667,030–211,667,875 | 368.1 kb | Distal (>10kb) Multiome HiCAR | 301 | |
| chr1:211,675,193–211,676,330 | 359.7 kb | Distal (>10kb) Multiome HiCAR | 936 | |
| chr1:211,695,364–211,695,890 | 339.8 kb | Distal (>10kb) Multiome HiCAR | 283 | |
| chr1:211,698,066–211,699,596 | 336.9 kb | Distal (>10kb) Multiome HiCAR | 651 | |
| chr1:211,829,926–211,831,171 | 204.8 kb | Distal (>10kb) Multiome | 682 | |
| chr1:211,889,249–211,890,017 | 145.9 kb | Distal (>10kb) Multiome | 139 | |
| chr1:211,895,246–211,895,795 | 140.0 kb | Distal (>10kb) Multiome | 267 | |
| chr1:212,034,569–212,036,407 | 83 bp | At TSS Multiome | 995 | |
| chr1:212,044,920–212,045,344 | 9.4 kb | Proximal (<10kb) | 12 | |
| chr1:212,214,185–212,214,767 | 179.1 kb | Distal (>10kb) Multiome | 99 | |
| chr1:212,284,406–212,286,816 | 249.6 kb | Distal (>10kb) Multiome | 1049 | |
| chr1:212,309,881–212,310,794 | 274.7 kb | Distal (>10kb) Multiome HiCAR | 183 | |
| chr1:212,315,914–212,316,445 | 280.6 kb | Distal (>10kb) Multiome HiCAR | 140 | |
| chr1:212,413,972–212,416,004 | 379.4 kb | Distal (>10kb) Multiome HiCAR | 833 |
Genomic view of the INTS7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.