INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for INTS4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = INTS4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of INTS4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:77,819,354–77,821,704 | 173.7 kb | Distal (>10kb) Multiome | 1047 | |
| chr11:77,994,042–77,995,347 | 196 bp | At TSS Multiome | 908 | |
| chr11:78,000,202–78,000,482 | 5.5 kb | Proximal (<10kb) | 205 | |
| chr11:78,022,454–78,023,411 | 28.5 kb | Distal (>10kb) Multiome | 526 | |
| chr11:78,079,393–78,080,040 | 85.1 kb | Distal (>10kb) Multiome | 1033 | |
| chr11:78,139,106–78,140,207 | 145.0 kb | Distal (>10kb) Multiome | 842 | |
| chr11:78,187,536–78,189,464 | 193.9 kb | Distal (>10kb) Multiome | 905 |
Genomic view of the INTS4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.