The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009]
Transcription factors with Perturb-seq knockdown data for INPPL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = INPPL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of INPPL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:71,928,161–71,929,328 | 295.1 kb | Distal (>10kb) Multiome | 869 | |
| chr11:72,040,697–72,041,585 | 182.9 kb | Distal (>10kb) Multiome | 586 | |
| chr11:72,080,144–72,081,188 | 143.3 kb | Distal (>10kb) Multiome | 789 | |
| chr11:72,088,078–72,088,746 | 135.6 kb | Distal (>10kb) Multiome | 50 | |
| chr11:72,102,846–72,104,062 | 120.6 kb | Distal (>10kb) Multiome | 870 | |
| chr11:72,111,979–72,113,129 | 111.4 kb | Distal (>10kb) Multiome | 901 | |
| chr11:72,222,505–72,225,138 | 557 bp | At TSS Multiome | 815 | |
| chr11:72,237,525–72,239,038 | 14.3 kb | Distal (>10kb) Multiome | 427 | |
| chr11:72,239,350–72,240,441 | 15.9 kb | Distal (>10kb) Multiome | 349 | |
| chr11:72,243,706–72,244,831 | 20.3 kb | Distal (>10kb) Multiome | 234 | |
| chr11:72,433,982–72,434,972 | 210.6 kb | Distal (>10kb) Multiome | 950 |
Genomic view of the INPPL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.