This gene encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2008]
Transcription factors with Perturb-seq knockdown data for INPP4A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = INPP4A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of INPP4A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:98,346,371–98,347,129 | 98.3 kb | Distal (>10kb) Multiome | 241 | |
| chr2:98,357,468–98,358,266 | 86.9 kb | Distal (>10kb) Multiome | 122 | |
| chr2:98,442,387–98,442,834 | 2.1 kb | Proximal (<10kb) | 23 | |
| chr2:98,444,269–98,445,711 | 68 bp | At TSS Multiome | 701 | |
| chr2:98,466,263–98,466,729 | 21.6 kb | Distal (>10kb) Multiome | 102 | |
| chr2:98,494,179–98,495,859 | 50.0 kb | Distal (>10kb) Multiome | 218 | |
| chr2:98,513,976–98,514,722 | 69.5 kb | Distal (>10kb) Multiome HiCAR | 137 | |
| chr2:98,608,079–98,608,886 | 163.6 kb | Distal (>10kb) Multiome | 1004 | |
| chr2:98,611,155–98,612,164 | 166.6 kb | Distal (>10kb) Multiome | 120 | |
| chr2:98,730,234–98,731,725 | 286.2 kb | Distal (>10kb) Multiome | 720 |
Genomic view of the INPP4A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.