This gene represents a member of the formin family of proteins. It is considered a diaphanous formin due to the presence of a diaphanous inhibitory domain located at the N-terminus of the encoded protein. Studies of a similar mouse protein indicate that the protein encoded by this locus may function in polymerization and depolymerization of actin filaments. Mutations at this locus have been associated with focal segmental glomerulosclerosis 5.[provided by RefSeq, Aug 2010]
Transcription factors with Perturb-seq knockdown data for INF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = INF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of INF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:104,395,353–104,396,036 | 294.0 kb | Distal (>10kb) Multiome | 83 | |
| chr14:104,563,886–104,564,429 | 125.5 kb | Distal (>10kb) Multiome | 258 | |
| chr14:104,604,320–104,605,057 | 84.8 kb | Distal (>10kb) Multiome | 410 | |
| chr14:104,644,552–104,645,399 | 44.7 kb | Distal (>10kb) Multiome | 73 | |
| chr14:104,650,132–104,650,778 | 39.2 kb | Distal (>10kb) Multiome | 479 | |
| chr14:104,677,345–104,678,671 | 11.6 kb | Distal (>10kb) Multiome | 661 | |
| chr14:104,681,399–104,683,204 | 7.5 kb | Proximal (<10kb) Multiome | 586 | |
| chr14:104,689,023–104,690,058 | 118 bp | At TSS Multiome | 571 | |
| chr14:104,708,563–104,709,104 | 19.2 kb | Distal (>10kb) Multiome | 300 | |
| chr14:104,723,348–104,724,675 | 34.4 kb | Distal (>10kb) Multiome | 710 | |
| chr14:104,752,085–104,753,760 | 63.3 kb | Distal (>10kb) Multiome | 924 | |
| chr14:104,768,378–104,769,330 | 79.2 kb | Distal (>10kb) Multiome | 614 | |
| chr14:104,793,970–104,794,513 | 104.6 kb | Distal (>10kb) Multiome | 302 | |
| chr14:104,795,078–104,796,304 | 106.2 kb | Distal (>10kb) Multiome | 456 | |
| chr14:104,799,612–104,801,541 | 110.0 kb | Distal (>10kb) Multiome | 749 | |
| chr14:104,815,517–104,816,820 | 126.5 kb | Distal (>10kb) Multiome | 1064 | |
| chr14:104,825,631–104,828,095 | 138.2 kb | Distal (>10kb) Multiome | 653 | |
| chr14:104,863,847–104,866,207 | 174.6 kb | Distal (>10kb) Multiome | 743 | |
| chr14:104,932,604–104,933,678 | 243.8 kb | Distal (>10kb) Multiome | 498 | |
| chr14:104,967,607–104,968,024 | 278.3 kb | Distal (>10kb) Multiome | 196 | |
| chr14:104,975,803–104,976,561 | 286.6 kb | Distal (>10kb) Multiome | 394 | |
| chr14:104,977,531–104,979,147 | 288.8 kb | Distal (>10kb) Multiome | 387 | |
| chr14:104,985,398–104,986,377 | 296.1 kb | Distal (>10kb) Multiome | 518 |
Genomic view of the INF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.