Involved in several processes, including nucleotide-binding activity oligomerization domain containing 2 signaling pathway; positive regulation of cytokine production; and positive regulation of intracellular signal transduction. Located in cytoplasm and nuclear body. Implicated in inflammatory bowel disease 29. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for INAVA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = INAVA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of INAVA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:200,620,328–200,621,096 | 270.5 kb | Distal (>10kb) Multiome | 739 | |
| chr1:200,669,293–200,670,631 | 221.4 kb | Distal (>10kb) Multiome | 1078 | |
| chr1:200,738,299–200,740,095 | 152.3 kb | Distal (>10kb) Multiome | 831 | |
| chr1:200,886,734–200,886,995 | 4.3 kb | Proximal (<10kb) | 142 | |
| chr1:200,888,382–200,888,733 | 2.6 kb | Proximal (<10kb) | 314 | |
| chr1:200,890,766–200,892,246 | 28 bp | At TSS Multiome | 761 | |
| chr1:200,915,808–200,916,700 | 25.0 kb | Distal (>10kb) Multiome | 219 | |
| chr1:201,014,162–201,014,786 | 123.2 kb | Distal (>10kb) Multiome | 160 | |
| chr1:201,020,041–201,020,958 | 129.1 kb | Distal (>10kb) Multiome | 289 | |
| chr1:201,021,071–201,021,621 | 130.0 kb | Distal (>10kb) Multiome | 164 | |
| chr1:201,022,936–201,024,467 | 132.4 kb | Distal (>10kb) Multiome | 436 | |
| chr1:201,113,946–201,115,250 | 223.0 kb | Distal (>10kb) Multiome | 594 | |
| chr1:201,153,600–201,155,169 | 263.1 kb | Distal (>10kb) Multiome | 713 | |
| chr1:201,170,516–201,172,002 | 279.6 kb | Distal (>10kb) Multiome | 988 |
Genomic view of the INAVA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.