Transcription factors with Perturb-seq knockdown data for IMPDH1P10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IMPDH1P10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IMPDH1P10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:201,130,677–201,131,103 | 8.9 kb | Proximal (<10kb) | 227 | |
| chr2:201,138,932–201,139,319 | 707 bp | At TSS | 7 | |
| chr2:201,139,450–201,139,812 | 214 bp | At TSS | 20 | |
| chr2:201,139,950–201,140,164 | at TSS | At TSS | 47 | |
| chr2:201,148,432–201,148,970 | 8.4 kb | Proximal (<10kb) | 63 |
Genomic view of the IMPDH1P10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.