The protein encoded by this gene, along with IMP3 and MPP10, is part of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) complex. This complex is necessary for the early cleavage steps of pre-18S ribosomal RNA processing. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for IMP4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IMP4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IMP4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:130,144,783–130,145,418 | 197.8 kb | Distal (>10kb) Multiome | 89 | |
| chr2:130,181,118–130,182,559 | 160.9 kb | Distal (>10kb) Multiome | 790 | |
| chr2:130,288,447–130,288,984 | 54.1 kb | Distal (>10kb) Multiome | 232 | |
| chr2:130,327,383–130,328,425 | 15.0 kb | Distal (>10kb) Multiome | 215 | |
| chr2:130,332,278–130,333,022 | 9.9 kb | Proximal (<10kb) | 438 | |
| chr2:130,336,899–130,337,857 | 5.5 kb | Proximal (<10kb) Multiome | 861 | |
| chr2:130,341,623–130,343,538 | 162 bp | At TSS Multiome | 1109 | |
| chr2:130,355,375–130,356,704 | 13.1 kb | Distal (>10kb) Multiome | 816 | |
| chr2:130,371,871–130,373,243 | 29.7 kb | Distal (>10kb) Multiome | 651 | |
| chr2:130,391,075–130,391,923 | 48.6 kb | Distal (>10kb) Multiome | 609 |
Genomic view of the IMP4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.