Transcription factors with Perturb-seq knockdown data for ILF3-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ILF3-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ILF3-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:10,352,359–10,354,435 | 299.9 kb | Distal (>10kb) Multiome | 447 | |
| chr19:10,380,209–10,381,218 | 273.2 kb | Distal (>10kb) Multiome | 874 | |
| chr19:10,403,282–10,404,914 | 250.2 kb | Distal (>10kb) Multiome | 794 | |
| chr19:10,416,245–10,417,312 | 237.2 kb | Distal (>10kb) Multiome | 988 | |
| chr19:10,417,499–10,421,409 | 233.6 kb | Distal (>10kb) Multiome | 801 | |
| chr19:10,424,198–10,424,839 | 229.3 kb | Distal (>10kb) Multiome | 563 | |
| chr19:10,431,990–10,432,435 | 221.7 kb | Distal (>10kb) Multiome | 301 | |
| chr19:10,460,915–10,461,960 | 192.5 kb | Distal (>10kb) Multiome | 340 | |
| chr19:10,502,251–10,503,615 | 151.1 kb | Distal (>10kb) Multiome | 1013 | |
| chr19:10,514,009–10,514,960 | 139.5 kb | Distal (>10kb) Multiome | 172 | |
| chr19:10,517,347–10,518,104 | 136.1 kb | Distal (>10kb) Multiome | 338 | |
| chr19:10,543,499–10,544,302 | 110.0 kb | Distal (>10kb) Multiome | 617 | |
| chr19:10,565,054–10,566,439 | 87.8 kb | Distal (>10kb) Multiome | 923 | |
| chr19:10,568,225–10,569,839 | 84.9 kb | Distal (>10kb) Multiome | 871 | |
| chr19:10,602,117–10,602,945 | 51.4 kb | Distal (>10kb) Multiome | 518 | |
| chr19:10,625,339–10,625,984 | 28.3 kb | Distal (>10kb) Multiome | 451 | |
| chr19:10,644,789–10,645,033 | 8.8 kb | Proximal (<10kb) | 430 | |
| chr19:10,653,364–10,655,129 | 252 bp | At TSS Multiome | 1086 | |
| chr19:10,656,013–10,656,180 | 2.1 kb | Proximal (<10kb) | 211 | |
| chr19:10,695,264–10,696,403 | 42.0 kb | Distal (>10kb) Multiome | 831 | |
| chr19:10,701,273–10,702,291 | 47.6 kb | Distal (>10kb) Multiome | 889 | |
| chr19:10,717,121–10,718,717 | 63.9 kb | Distal (>10kb) Multiome | 849 | |
| chr19:10,835,171–10,836,835 | 182.0 kb | Distal (>10kb) Multiome | 1096 | |
| chr19:10,870,403–10,872,620 | 217.3 kb | Distal (>10kb) Multiome | 714 | |
| chr19:10,928,331–10,929,395 | 274.8 kb | Distal (>10kb) Multiome | 860 |
Genomic view of the ILF3-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.