Predicted to enable cell-cell adhesion mediator activity. Predicted to be involved in axon guidance; dendrite self-avoidance; and homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to act upstream of or within dendrite development and regulation of synapse organization. Predicted to be located in dendrite and inhibitory synapse. Predicted to be active in axon; glutamatergic synapse; and postsynaptic density membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for IGSF9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IGSF9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IGSF9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:159,780,492–159,781,699 | 164.7 kb | Distal (>10kb) Multiome | 641 | |
| chr1:159,853,905–159,855,297 | 91.0 kb | Distal (>10kb) Multiome | 474 | |
| chr1:159,899,910–159,900,706 | 45.3 kb | Distal (>10kb) Multiome | 349 | |
| chr1:159,922,909–159,926,224 | 20.1 kb | Distal (>10kb) Multiome | 922 | |
| chr1:159,929,315–159,930,329 | 15.9 kb | Distal (>10kb) Multiome | 235 | |
| chr1:159,936,265–159,937,075 | 9.0 kb | Proximal (<10kb) Multiome | 355 | |
| chr1:159,945,025–159,946,368 | 176 bp | At TSS Multiome | 624 | |
| chr1:160,031,268–160,032,381 | 86.3 kb | Distal (>10kb) Multiome | 780 | |
| chr1:160,046,290–160,047,082 | 101.1 kb | Distal (>10kb) Multiome | 540 | |
| chr1:160,069,829–160,071,049 | 124.8 kb | Distal (>10kb) Multiome | 419 | |
| chr1:160,083,809–160,084,575 | 138.6 kb | Distal (>10kb) Multiome | 327 | |
| chr1:160,095,707–160,096,231 | 150.4 kb | Distal (>10kb) Multiome | 79 | |
| chr1:160,097,214–160,099,572 | 153.3 kb | Distal (>10kb) Multiome | 659 | |
| chr1:160,100,845–160,101,543 | 155.6 kb | Distal (>10kb) Multiome | 530 | |
| chr1:160,169,049–160,170,141 | 224.1 kb | Distal (>10kb) Multiome | 330 | |
| chr1:160,192,913–160,193,769 | 247.7 kb | Distal (>10kb) Multiome | 551 | |
| chr1:160,204,860–160,206,035 | 259.8 kb | Distal (>10kb) Multiome | 637 |
Genomic view of the IGSF9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.