This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for IGSF8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IGSF8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IGSF8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:159,853,905–159,855,297 | 243.9 kb | Distal (>10kb) Multiome | 474 | |
| chr1:159,899,910–159,900,706 | 198.4 kb | Distal (>10kb) Multiome | 349 | |
| chr1:159,915,918–159,916,996 | 182.2 kb | Distal (>10kb) Multiome | 465 | |
| chr1:159,922,909–159,926,224 | 173.1 kb | Distal (>10kb) Multiome | 922 | |
| chr1:159,929,315–159,930,329 | 168.9 kb | Distal (>10kb) Multiome | 235 | |
| chr1:159,936,265–159,937,075 | 162.0 kb | Distal (>10kb) Multiome | 355 | |
| chr1:159,945,025–159,946,368 | 152.9 kb | Distal (>10kb) Multiome | 624 | |
| chr1:160,031,268–160,032,381 | 66.7 kb | Distal (>10kb) Multiome | 780 | |
| chr1:160,046,290–160,047,082 | 51.9 kb | Distal (>10kb) Multiome | 540 | |
| chr1:160,069,829–160,071,049 | 28.2 kb | Distal (>10kb) Multiome | 419 | |
| chr1:160,083,809–160,084,575 | 14.4 kb | Distal (>10kb) Multiome | 327 | |
| chr1:160,095,707–160,096,231 | 2.6 kb | Proximal (<10kb) Multiome | 79 | |
| chr1:160,096,759–160,097,108 | 1.5 kb | Proximal (<10kb) | 101 | |
| chr1:160,097,214–160,099,572 | 271 bp | At TSS Multiome | 659 | |
| chr1:160,100,845–160,101,543 | 2.6 kb | Proximal (<10kb) Multiome | 530 | |
| chr1:160,169,049–160,170,141 | 71.1 kb | Distal (>10kb) Multiome HiCAR | 330 | |
| chr1:160,192,913–160,193,769 | 94.7 kb | Distal (>10kb) Multiome | 551 | |
| chr1:160,204,860–160,206,035 | 106.8 kb | Distal (>10kb) Multiome | 637 | |
| chr1:160,261,515–160,263,143 | 163.9 kb | Distal (>10kb) Multiome | 992 | |
| chr1:160,284,609–160,285,332 | 186.5 kb | Distal (>10kb) Multiome | 638 | |
| chr1:160,342,945–160,343,700 | 244.7 kb | Distal (>10kb) Multiome | 868 |
Genomic view of the IGSF8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.