The protein encoded by this gene is an immunoglobulin-like membrane protein containing several V-type Ig-like domains. A mutation in this gene has been associated with bilateral nasolacrimal duct obstruction (LCDD). [provided by RefSeq, Jun 2016]
Transcription factors with Perturb-seq knockdown data for IGSF3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IGSF3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IGSF3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:116,372,503–116,374,831 | 294.5 kb | Distal (>10kb) Multiome | 903 | |
| chr1:116,415,510–116,416,727 | 251.7 kb | Distal (>10kb) Multiome | 525 | |
| chr1:116,418,287–116,418,947 | 249.1 kb | Distal (>10kb) Multiome | 835 | |
| chr1:116,420,956–116,421,526 | 246.6 kb | Distal (>10kb) Multiome | 81 | |
| chr1:116,485,040–116,485,738 | 182.3 kb | Distal (>10kb) Multiome | 519 | |
| chr1:116,569,966–116,571,655 | 96.8 kb | Distal (>10kb) Multiome | 829 | |
| chr1:116,666,816–116,668,150 | 27 bp | At TSS Multiome | 530 | |
| chr1:116,672,557–116,672,845 | 4.8 kb | Proximal (<10kb) | 182 | |
| chr1:116,909,571–116,911,117 | 242.3 kb | Distal (>10kb) Multiome | 645 |
Genomic view of the IGSF3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.