Predicted to act upstream of or within motor behavior and neuromuscular process controlling balance. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for IGLON5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IGLON5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IGLON5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:51,016,816–51,017,391 | 294.6 kb | Distal (>10kb) Multiome | 394 | |
| chr19:51,064,766–51,065,479 | 246.5 kb | Distal (>10kb) Multiome | 227 | |
| chr19:51,107,794–51,109,056 | 203.2 kb | Distal (>10kb) Multiome | 750 | |
| chr19:51,311,132–51,312,279 | 84 bp | At TSS Multiome | 99 | |
| chr19:51,327,535–51,328,038 | 16.2 kb | Distal (>10kb) Multiome | 288 | |
| chr19:51,338,815–51,340,814 | 28.3 kb | Distal (>10kb) Multiome | 827 | |
| chr19:51,365,646–51,368,695 | 56.1 kb | Distal (>10kb) Multiome | 1057 | |
| chr19:51,390,425–51,391,164 | 79.0 kb | Distal (>10kb) Multiome | 171 | |
| chr19:51,393,803–51,394,830 | 82.8 kb | Distal (>10kb) Multiome | 725 | |
| chr19:51,421,811–51,422,246 | 110.4 kb | Distal (>10kb) Multiome | 848 | |
| chr19:51,570,986–51,571,539 | 259.5 kb | Distal (>10kb) Multiome | 515 | |
| chr19:51,593,934–51,594,889 | 282.8 kb | Distal (>10kb) Multiome | 581 |
Genomic view of the IGLON5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.