Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for IGFLR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IGFLR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IGFLR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:35,509,786–35,510,900 | 230.9 kb | Distal (>10kb) Multiome | 650 | |
| chr19:35,545,067–35,546,126 | 195.7 kb | Distal (>10kb) Multiome | 879 | |
| chr19:35,557,343–35,558,684 | 183.3 kb | Distal (>10kb) Multiome | 452 | |
| chr19:35,612,546–35,613,176 | 128.6 kb | Distal (>10kb) Multiome | 778 | |
| chr19:35,628,465–35,629,474 | 112.4 kb | Distal (>10kb) Multiome | 889 | |
| chr19:35,643,064–35,645,730 | 97.8 kb | Distal (>10kb) Multiome | 1010 | |
| chr19:35,648,040–35,648,575 | 93.1 kb | Distal (>10kb) Multiome | 599 | |
| chr19:35,673,179–35,673,643 | 67.9 kb | Distal (>10kb) Multiome | 311 | |
| chr19:35,702,152–35,702,985 | 38.9 kb | Distal (>10kb) Multiome | 662 | |
| chr19:35,716,025–35,718,811 | 23.6 kb | Distal (>10kb) Multiome | 1018 | |
| chr19:35,740,083–35,741,430 | 536 bp | At TSS Multiome | 829 | |
| chr19:35,744,481–35,746,086 | 3.9 kb | Proximal (<10kb) Multiome | 679 | |
| chr19:35,748,170–35,749,017 | 7.1 kb | Proximal (<10kb) Multiome | 749 | |
| chr19:35,757,432–35,758,657 | 16.8 kb | Distal (>10kb) Multiome | 851 | |
| chr19:35,767,601–35,768,256 | 26.6 kb | Distal (>10kb) Multiome | 276 | |
| chr19:35,775,066–35,776,063 | 34.2 kb | Distal (>10kb) Multiome | 474 | |
| chr19:35,784,357–35,785,306 | 43.4 kb | Distal (>10kb) Multiome | 183 | |
| chr19:35,860,621–35,861,651 | 120.0 kb | Distal (>10kb) Multiome | 299 | |
| chr19:35,868,369–35,868,860 | 127.1 kb | Distal (>10kb) Multiome | 320 | |
| chr19:35,869,343–35,870,482 | 128.6 kb | Distal (>10kb) Multiome | 492 | |
| chr19:35,899,240–35,900,760 | 158.3 kb | Distal (>10kb) Multiome | 751 | |
| chr19:35,931,342–35,932,167 | 190.3 kb | Distal (>10kb) Multiome | 835 | |
| chr19:35,936,083–35,936,704 | 195.1 kb | Distal (>10kb) Multiome | 417 | |
| chr19:35,986,945–35,987,622 | 245.9 kb | Distal (>10kb) Multiome | 363 | |
| chr19:35,994,796–35,995,940 | 253.9 kb | Distal (>10kb) Multiome | 897 | |
| chr19:36,013,972–36,014,810 | 273.0 kb | Distal (>10kb) Multiome | 623 | |
| chr19:36,032,424–36,033,187 | 291.5 kb | Distal (>10kb) Multiome | 179 |
Genomic view of the IGFLR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.