Predicted to be involved in cell-cell adhesion. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for IGDCC4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IGDCC4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IGDCC4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:65,132,889–65,133,960 | 289.2 kb | Distal (>10kb) Multiome | 775 | |
| chr15:65,184,434–65,185,938 | 237.5 kb | Distal (>10kb) Multiome | 985 | |
| chr15:65,286,029–65,287,330 | 136.0 kb | Distal (>10kb) Multiome | 919 | |
| chr15:65,295,595–65,297,682 | 126.7 kb | Distal (>10kb) Multiome | 1039 | |
| chr15:65,299,879–65,301,676 | 121.9 kb | Distal (>10kb) Multiome | 464 | |
| chr15:65,303,709–65,305,825 | 118.1 kb | Distal (>10kb) Multiome | 1230 | |
| chr15:65,355,116–65,356,095 | 67.4 kb | Distal (>10kb) Multiome | 288 | |
| chr15:65,376,859–65,378,657 | 44.9 kb | Distal (>10kb) Multiome | 612 | |
| chr15:65,384,869–65,386,083 | 37.2 kb | Distal (>10kb) Multiome | 703 | |
| chr15:65,400,812–65,401,824 | 21.5 kb | Distal (>10kb) Multiome | 406 | |
| chr15:65,414,873–65,415,582 | 7.7 kb | Proximal (<10kb) Multiome | 333 | |
| chr15:65,416,946–65,417,365 | 5.6 kb | Proximal (<10kb) | 146 | |
| chr15:65,421,061–65,422,050 | 1.4 kb | Proximal (<10kb) Multiome | 457 | |
| chr15:65,422,462–65,423,579 | 131 bp | At TSS Multiome | 450 | |
| chr15:65,517,110–65,517,892 | 94.7 kb | Distal (>10kb) Multiome | 1031 | |
| chr15:65,521,411–65,521,886 | 98.6 kb | Distal (>10kb) Multiome | 35 | |
| chr15:65,530,109–65,531,265 | 107.5 kb | Distal (>10kb) Multiome | 922 | |
| chr15:65,610,849–65,611,766 | 188.3 kb | Distal (>10kb) Multiome | 1108 |
Genomic view of the IGDCC4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.