This gene encodes a protein that was identified as a cellular interacting partner of non-structural protein 10 of the severe acute respiratory syndrome coronavirus (SARS-CoV). The encoded protein may function as a negative regulator of transcription. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Transcription factors with Perturb-seq knockdown data for IFTAP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IFTAP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IFTAP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:36,375,916–36,378,030 | 217.0 kb | Distal (>10kb) Multiome | 474 | |
| chr11:36,509,026–36,510,770 | 84.3 kb | Distal (>10kb) Multiome | 984 | |
| chr11:36,594,101–36,595,067 | 29 bp | At TSS Multiome | 763 | |
| chr11:36,600,259–36,600,494 | 5.7 kb | Proximal (<10kb) | 39 | |
| chr11:36,746,908–36,747,627 | 152.7 kb | Distal (>10kb) Multiome | 367 |
Genomic view of the IFTAP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.