The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for IFNLR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IFNLR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IFNLR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:23,958,982–23,960,271 | 227.5 kb | Distal (>10kb) Multiome | 1051 | |
| chr1:23,979,815–23,981,031 | 206.9 kb | Distal (>10kb) Multiome | 1078 | |
| chr1:23,998,624–23,999,076 | 188.4 kb | Distal (>10kb) Multiome | 19 | |
| chr1:24,150,246–24,151,570 | 36.6 kb | Distal (>10kb) Multiome | 480 | |
| chr1:24,186,980–24,187,928 | 117 bp | At TSS Multiome | 546 | |
| chr1:24,321,723–24,322,705 | 135.0 kb | Distal (>10kb) Multiome | 514 | |
| chr1:24,413,280–24,414,095 | 226.5 kb | Distal (>10kb) Multiome | 627 | |
| chr1:24,415,211–24,416,076 | 228.3 kb | Distal (>10kb) Multiome | 686 |
Genomic view of the IFNLR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.