This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for IFNGR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IFNGR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IFNGR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:33,229,605–33,230,926 | 173.5 kb | Distal (>10kb) Multiome | 722 | |
| chr21:33,266,016–33,266,841 | 137.1 kb | Distal (>10kb) Multiome | 604 | |
| chr21:33,324,272–33,325,694 | 78.6 kb | Distal (>10kb) Multiome | 1015 | |
| chr21:33,402,567–33,402,985 | 571 bp | At TSS Multiome | 218 | |
| chr21:33,403,116–33,404,351 | 50 bp | At TSS Multiome | 570 | |
| chr21:33,478,861–33,480,615 | 76.7 kb | Distal (>10kb) Multiome | 839 | |
| chr21:33,491,033–33,492,145 | 88.2 kb | Distal (>10kb) Multiome | 740 | |
| chr21:33,541,871–33,543,585 | 138.6 kb | Distal (>10kb) Multiome | 996 | |
| chr21:33,587,947–33,589,340 | 185.3 kb | Distal (>10kb) Multiome | 866 | |
| chr21:33,641,108–33,643,411 | 238.7 kb | Distal (>10kb) Multiome | 1018 |
Genomic view of the IFNGR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.